Stage plot pro 2.9.1
The lowest dose of patiromer (8.4 g) was used in 721 encounters (81.8%), and in 725 encounters (82.3%), no further doses of a potassium binder were required. Both absolute and relative potassium reduction from baseline varied across baseline hyperkalemia severity but not by care setting. The mean (SD) baseline serum potassium level was 5.60 (0.35) mEq/L (to convert to mmol/L, multiply by 1.0), and within the first 6 hours after patiromer administration, the mean (SD) potassium reduction was 0.50 (0.56) mEq/L ( P < .001). Results Among 881 encounters of patiromer treatment, the mean (SD) age of patients was 67.4 (14.4) years 463 encounters (52.6%) were for male patients, and most (338 ) were for patients who identified as non-Hispanic Black. Key secondary outcomes were the incidence of hypokalemia and potassium reduction stratified by baseline potassium level and care setting. Main Outcomes and Measure The primary outcome was the mean absolute reduction in serum potassium level from baseline at 3 distinct time intervals after patiromer administration: 0 to 6 hours, greater than 6 to 12 hours, and greater than 12 to 24 hours.
Data analysis was conducted between June 2020 and February 2021.Įxposures A single dose of oral patiromer (8.4 g, 16.8 g, or 25.2 g). Objective To evaluate the outcomes associated with patiromer as monotherapy in patients with acute hyperkalemia in an acute care setting.ĭesign, Setting, and Participants This cohort study used electronic health record data from adult patients treated with patiromer for acute hyperkalemia in emergency departments, inpatient units, and intensive care units at an urban, academic medical center in the Bronx, New York, between January 30, 2018, and December 30, 2019.
Importance Hyperkalemia is a common electrolyte disorder in hospitalized patients however, the clinical usefulness of administering patiromer for reduction of serum potassium levels in this setting is unknown. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.